The 2009 H1N1 Pandemic Influenza Virus: What Next?
Identifieur interne : 000E13 ( Main/Exploration ); précédent : 000E12; suivant : 000E14The 2009 H1N1 Pandemic Influenza Virus: What Next?
Auteurs : David M. Morens ; Jeffery K. Taubenberger ; Anthony S. FauciSource :
- mBio [ 2150-7511 ] ; 2010.
Abstract
History suggests that the 2009 pandemic H1N1 influenza virus faces extinction unless it mutates to avoid already high global population immunity. The immune escape mechanisms potentially at its disposal include antigenic drift, antigenic shift via genetic reassortment, and intrasubtypic reassortment. Going back to the late 19th century, the evolutionary histories of past pandemic viruses are examined in an effort to better understand the nature and extent of the immune pressures faced by the 2009 pandemic virus in the immediate future. While human influenza viruses have often surprised us, available evidence leads to the hope that the current pandemic virus will continue to cause low or moderate mortality rates if it does not become extinct.
Url:
DOI: 10.1128/mBio.00211-10
PubMed: 20877580
PubMed Central: 2945198
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000500
- to stream Pmc, to step Curation: 000500
- to stream Pmc, to step Checkpoint: 000880
- to stream Ncbi, to step Merge: 000569
- to stream Ncbi, to step Curation: 000569
- to stream Ncbi, to step Checkpoint: 000569
- to stream Main, to step Merge: 000E19
- to stream Main, to step Curation: 000E13
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The 2009 H1N1 Pandemic Influenza Virus: What Next?</title><author><name sortKey="Morens, David M" sort="Morens, David M" uniqKey="Morens D" first="David M." last="Morens">David M. Morens</name></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name></author><author><name sortKey="Fauci, Anthony S" sort="Fauci, Anthony S" uniqKey="Fauci A" first="Anthony S." last="Fauci">Anthony S. Fauci</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20877580</idno><idno type="pmc">2945198</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945198</idno><idno type="RBID">PMC:2945198</idno><idno type="doi">10.1128/mBio.00211-10</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000500</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000500</idno><idno type="wicri:Area/Pmc/Curation">000500</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000500</idno><idno type="wicri:Area/Pmc/Checkpoint">000880</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000880</idno><idno type="wicri:Area/Ncbi/Merge">000569</idno><idno type="wicri:Area/Ncbi/Curation">000569</idno><idno type="wicri:Area/Ncbi/Checkpoint">000569</idno><idno type="wicri:Area/Main/Merge">000E19</idno><idno type="wicri:Area/Main/Curation">000E13</idno><idno type="wicri:Area/Main/Exploration">000E13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The 2009 H1N1 Pandemic Influenza Virus: What Next?</title><author><name sortKey="Morens, David M" sort="Morens, David M" uniqKey="Morens D" first="David M." last="Morens">David M. Morens</name></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name></author><author><name sortKey="Fauci, Anthony S" sort="Fauci, Anthony S" uniqKey="Fauci A" first="Anthony S." last="Fauci">Anthony S. Fauci</name></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>History suggests that the 2009 pandemic H1N1 influenza virus faces extinction unless it mutates to avoid already high global population immunity. The immune escape mechanisms potentially at its disposal include antigenic drift, antigenic shift via genetic reassortment, and intrasubtypic reassortment. Going back to the late 19th century, the evolutionary histories of past pandemic viruses are examined in an effort to better understand the nature and extent of the immune pressures faced by the 2009 pandemic virus in the immediate future. While human influenza viruses have often surprised us, available evidence leads to the hope that the current pandemic virus will continue to cause low or moderate mortality rates if it does not become extinct.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Morens, D" uniqKey="Morens D">D. Morens</name></author><author><name sortKey="Taubenberger, J" uniqKey="Taubenberger J">J. Taubenberger</name></author><author><name sortKey="Fauci, A" uniqKey="Fauci A">A. Fauci</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, E C" uniqKey="Holmes E">E. C. Holmes</name></author><author><name sortKey="Ghedin, E" uniqKey="Ghedin E">E. Ghedin</name></author><author><name sortKey="Miller, N" uniqKey="Miller N">N. Miller</name></author><author><name sortKey="Taylor, J" uniqKey="Taylor J">J. Taylor</name></author><author><name sortKey="Bao, Y" uniqKey="Bao Y">Y. Bao</name></author><author><name sortKey="George, K St" uniqKey="George K">K. St. George</name></author><author><name sortKey="Grenfell, B T" uniqKey="Grenfell B">B. T. Grenfell</name></author><author><name sortKey="Salzberg, S L" uniqKey="Salzberg S">S. L. Salzberg</name></author><author><name sortKey="Fraser, C M" uniqKey="Fraser C">C. M. Fraser</name></author><author><name sortKey="Lipman, D J" uniqKey="Lipman D">D. J. Lipman</name></author><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J. K. Taubenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A. Rambaut</name></author><author><name sortKey="Pybus, O G" uniqKey="Pybus O">O. G. Pybus</name></author><author><name sortKey="Nelson, M I" uniqKey="Nelson M">M. I. Nelson</name></author><author><name sortKey="Viboud, C" uniqKey="Viboud C">C. Viboud</name></author><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J. K. Taubenberger</name></author><author><name sortKey="Holmes, E C" uniqKey="Holmes E">E. C. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hancock, K" uniqKey="Hancock K">K. Hancock</name></author><author><name sortKey="Veguilla, V" uniqKey="Veguilla V">V. Veguilla</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W. Zhong</name></author><author><name sortKey="Butler, E N" uniqKey="Butler E">E. N. Butler</name></author><author><name sortKey="Sun, H" uniqKey="Sun H">H. Sun</name></author><author><name sortKey="Liu, F" uniqKey="Liu F">F. Liu</name></author><author><name sortKey="Dong, L" uniqKey="Dong L">L. Dong</name></author><author><name sortKey="Devos, J R" uniqKey="Devos J">J. R. DeVos</name></author><author><name sortKey="Gargiullo, P M" uniqKey="Gargiullo P">P. M. Gargiullo</name></author><author><name sortKey="Brammer, T L" uniqKey="Brammer T">T. L. Brammer</name></author><author><name sortKey="Cox, N J" uniqKey="Cox N">N. J. Cox</name></author><author><name sortKey="Tumpey, T M" uniqKey="Tumpey T">T. M. Tumpey</name></author><author><name sortKey="Katz, J M" uniqKey="Katz J">J. M. Katz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davenport, F" uniqKey="Davenport F">F. Davenport</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kash, J C" uniqKey="Kash J">J. C. Kash</name></author><author><name sortKey="Qi, L" uniqKey="Qi L">L. Qi</name></author><author><name sortKey="Dugan, V G" uniqKey="Dugan V">V. G. Dugan</name></author><author><name sortKey="Jagger, B W" uniqKey="Jagger B">B. W. Jagger</name></author><author><name sortKey="Hrabal, R J" uniqKey="Hrabal R">R. J. Hrabal</name></author><author><name sortKey="Memoli, M J" uniqKey="Memoli M">M. J. Memoli</name></author><author><name sortKey="Morens, D M" uniqKey="Morens D">D. M. Morens</name></author><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J. K. Taubenberger</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Chin, T" uniqKey="Chin T">T. Chin</name></author><author><name sortKey="Foley, J" uniqKey="Foley J">J. Foley</name></author><author><name sortKey="Doto, I" uniqKey="Doto I">I. Doto</name></author><author><name sortKey="Gravelle, C" uniqKey="Gravelle C">C. Gravelle</name></author><author><name sortKey="Weston, J" uniqKey="Weston J">J. Weston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greenbaum, J A" uniqKey="Greenbaum J">J. A. Greenbaum</name></author><author><name sortKey="Kotturi, M F" uniqKey="Kotturi M">M. F. Kotturi</name></author><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y. Kim</name></author><author><name sortKey="Oseroff, C" uniqKey="Oseroff C">C. Oseroff</name></author><author><name sortKey="Vaughan, K" uniqKey="Vaughan K">K. Vaughan</name></author><author><name sortKey="Salimi, N" uniqKey="Salimi N">N. Salimi</name></author><author><name sortKey="Vita, R" uniqKey="Vita R">R. Vita</name></author><author><name sortKey="Ponomarenko, J" uniqKey="Ponomarenko J">J. Ponomarenko</name></author><author><name sortKey="Scheuermann, R H" uniqKey="Scheuermann R">R. H. Scheuermann</name></author><author><name sortKey="Sette, A" uniqKey="Sette A">A. Sette</name></author><author><name sortKey="Peters, B" uniqKey="Peters B">B. Peters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adalja, A A" uniqKey="Adalja A">A. A. Adalja</name></author><author><name sortKey="Henderson, D A" uniqKey="Henderson D">D. A. Henderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morens, D M" uniqKey="Morens D">D. M. Morens</name></author><author><name sortKey="Burke, D S" uniqKey="Burke D">D. S. Burke</name></author><author><name sortKey="Halstead, S B" uniqKey="Halstead S">S. B. Halstead</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morens, D M" uniqKey="Morens D">D. M. Morens</name></author><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J. K. Taubenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, J" uniqKey="Taubenberger J">J. Taubenberger</name></author><author><name sortKey="Morens, D M" uniqKey="Morens D">D. M. Morens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, M I" uniqKey="Nelson M">M. I. Nelson</name></author><author><name sortKey="Viboud, C" uniqKey="Viboud C">C. Viboud</name></author><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L. Simonsen</name></author><author><name sortKey="Bennet, R T" uniqKey="Bennet R">R. T. Bennet</name></author><author><name sortKey="Griesemer, S B" uniqKey="Griesemer S">S. B. Griesemer</name></author><author><name sortKey="St George, K" uniqKey="St George K">K. St. George</name></author><author><name sortKey="Taylor, J" uniqKey="Taylor J">J. Taylor</name></author><author><name sortKey="Spiro, D J" uniqKey="Spiro D">D. J. Spiro</name></author><author><name sortKey="Sengamalay, N A" uniqKey="Sengamalay N">N. A. Sengamalay</name></author><author><name sortKey="Ghedin, E" uniqKey="Ghedin E">E. Ghedin</name></author><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J. K. Taubenberger</name></author><author><name sortKey="Holmes, E C" uniqKey="Holmes E">E. C. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindstrom, S E" uniqKey="Lindstrom S">S. E. Lindstrom</name></author><author><name sortKey="Cox, N J" uniqKey="Cox N">N. J. Cox</name></author><author><name sortKey="Klimov, A" uniqKey="Klimov A">A. Klimov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fitch, W M" uniqKey="Fitch W">W. M. Fitch</name></author><author><name sortKey="Leiter, J M" uniqKey="Leiter J">J. M. Leiter</name></author><author><name sortKey="Li, X Q" uniqKey="Li X">X. Q. Li</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Philip, R" uniqKey="Philip R">R. Philip</name></author><author><name sortKey="Lackman, D" uniqKey="Lackman D">D. Lackman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilbourne, E" uniqKey="Kilbourne E">E. Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davenport, F" uniqKey="Davenport F">F. Davenport</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noble, G" uniqKey="Noble G">G. Noble</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dauer, C" uniqKey="Dauer C">C. Dauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dauer, C" uniqKey="Dauer C">C. Dauer</name></author><author><name sortKey="Serfling, R" uniqKey="Serfling R">R. Serfling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ailing, D" uniqKey="Ailing D">D. Ailing</name></author><author><name sortKey="Blackwelder, W" uniqKey="Blackwelder W">W. Blackwelder</name></author><author><name sortKey="Stuart Harris, C" uniqKey="Stuart Harris C">C. Stuart-Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, K" uniqKey="Choi K">K. Choi</name></author><author><name sortKey="Thacker, S" uniqKey="Thacker S">S. Thacker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stroup, D" uniqKey="Stroup D">D. Stroup</name></author><author><name sortKey="Thacker, S" uniqKey="Thacker S">S. Thacker</name></author><author><name sortKey="Herndon, J" uniqKey="Herndon J">J. Herndon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L. Simonsen</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M. Clarke</name></author><author><name sortKey="Stroup, D" uniqKey="Stroup D">D. Stroup</name></author><author><name sortKey="Williamson, G" uniqKey="Williamson G">G. Williamson</name></author><author><name sortKey="Arden, N" uniqKey="Arden N">N. Arden</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N. Cox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, W" uniqKey="Thompson W">W. Thompson</name></author><author><name sortKey="Shay, D" uniqKey="Shay D">D. Shay</name></author><author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E. Weintraub</name></author><author><name sortKey="Brammer, L" uniqKey="Brammer L">L. Brammer</name></author><author><name sortKey="Cox, N J" uniqKey="Cox N">N. J. Cox</name></author><author><name sortKey="Anderson, L" uniqKey="Anderson L">L. Anderson</name></author><author><name sortKey="Fukuda, K" uniqKey="Fukuda K">K. Fukuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foppa, I" uniqKey="Foppa I">I. Foppa</name></author><author><name sortKey="Hossain, M" uniqKey="Hossain M">M. Hossain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Layne, S P" uniqKey="Layne S">S. P. Layne</name></author><author><name sortKey="Monto, A S" uniqKey="Monto A">A. S. Monto</name></author><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J. K. Taubenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bastien, N" uniqKey="Bastien N">N. Bastien</name></author><author><name sortKey="Antonishyn, N A" uniqKey="Antonishyn N">N. A. Antonishyn</name></author><author><name sortKey="Brandt, K" uniqKey="Brandt K">K. Brandt</name></author><author><name sortKey="Wong, C E" uniqKey="Wong C">C. E. Wong</name></author><author><name sortKey="Chokani, K" uniqKey="Chokani K">K. Chokani</name></author><author><name sortKey="Vegh, N" uniqKey="Vegh N">N. Vegh</name></author><author><name sortKey="Horsman, G B" uniqKey="Horsman G">G. B. Horsman</name></author><author><name sortKey="Tyler, S" uniqKey="Tyler S">S. Tyler</name></author><author><name sortKey="Graham, M R" uniqKey="Graham M">M. R. Graham</name></author><author><name sortKey="Plummer, F A" uniqKey="Plummer F">F. A. Plummer</name></author><author><name sortKey="Levett, P N" uniqKey="Levett P">P. N. Levett</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Glezen, W P" uniqKey="Glezen W">W. P. Glezen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, J" uniqKey="Taubenberger J">J. Taubenberger</name></author><author><name sortKey="Kash, J" uniqKey="Kash J">J. Kash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L. Simonsen</name></author><author><name sortKey="Clarke, M J" uniqKey="Clarke M">M. J. Clarke</name></author><author><name sortKey="Schonberger, L B" uniqKey="Schonberger L">L. B. Schonberger</name></author><author><name sortKey="Arden, N H" uniqKey="Arden N">N. H. Arden</name></author><author><name sortKey="Cox, N J" uniqKey="Cox N">N. J. Cox</name></author><author><name sortKey="Fukuda, K" uniqKey="Fukuda K">K. Fukuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiore, A" uniqKey="Fiore A">A. Fiore</name></author><author><name sortKey="Uyeki, T" uniqKey="Uyeki T">T. Uyeki</name></author><author><name sortKey="Broder, K" uniqKey="Broder K">K. Broder</name></author><author><name sortKey="Finelli, L" uniqKey="Finelli L">L. Finelli</name></author><author><name sortKey="Euler, G" uniqKey="Euler G">G. Euler</name></author><author><name sortKey="Singleton, J" uniqKey="Singleton J">J. Singleton</name></author><author><name sortKey="Iskander, J K" uniqKey="Iskander J">J. K. Iskander</name></author><author><name sortKey="Wortley, P M" uniqKey="Wortley P">P. M. Wortley</name></author><author><name sortKey="Shay, D K" uniqKey="Shay D">D. K. Shay</name></author><author><name sortKey="Bresee, J S" uniqKey="Bresee J">J. S. Bresee</name></author><author><name sortKey="Cox, N J" uniqKey="Cox N">N. J. Cox</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Fauci, Anthony S" sort="Fauci, Anthony S" uniqKey="Fauci A" first="Anthony S." last="Fauci">Anthony S. Fauci</name><name sortKey="Morens, David M" sort="Morens, David M" uniqKey="Morens D" first="David M." last="Morens">David M. Morens</name><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E13 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E13 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2945198
|texte= The 2009 H1N1 Pandemic Influenza Virus: What Next?
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20877580" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |